2010•Zhonghua neifenmi daixie zazhiRequires access
Relationship of serum free fatty acid levels with insulin secretion and insulin resistance in gestational diabetes mellitus
Jianping Chu, Jialin Li, Yan-wen Niu, Lin-yun Wu, Li Li, Zhou-hong Mao
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Abstract
Serum free fatty acids and insulin levels at 3:00,5:00,and after 75 g glucose load were measured in 36 cases of gestational diabetes mellitus(GDM,gestational age from 24 to 36 weeks)and 30 healthy controls.Insulin resistance and insulin secretion were compared between GDM group and the controls.The Results showed that increased serum free fatty acids in nocturnal and after glucose load state were both associated with insulin resistance in GDM[insulin:(7.18±3.19)vs(5.05±1.80)mIU/L(3:00),(8.19±4.42)vs(5.31±1.82)mIU/L(5:00),(59.18±30.85)vs(40.52±15.07)mIU/L(after glucose load);free fatty-acid:(0.39±0.20)vs(0.23±0.11)mmol/L(3:00),(0.46±0.17)vs(0.29±0.12)mmol/L(5:00),(0.19±0.13)vs(0.09±0.06)mmol/L(after glucose load);all P<0.01].The impaired free fatty acid clearance during 30 min after glucose load was associated with early phase insulin secretion deficiency.
Key words:
Gestational diabetes mellitus; Fatty acids,nonesterified; Insulin resistance; Insulin secretion