Clinical Analysis of 53 Patients With Myeloproliferative Neoplasms

Objective To enhance the awareness of myeloproliferative neoplasms(MPN)and improve the diagnosis and treatment of the diseases.Methods From May 2007 to February 2012,a total of 53 cases of MPN patients who were treated by Xinghua People's Hospital were included in this study. A retrospective analysis of these patients' clinical data and laboratory test results were carried out.Results ① The peak age of MPN onset was 40 to 79 years old,accounting for 86.79％ (46/53). Chronic myeloid leukemia(CML) was the most common of these patients,accounting for 66.04％ (35/53).Splenomegaly was a typical clinical manifestations for MPN patients and there were 41 splenomegaly patients in all of the cases,accounting for77.36％. () There were significant differences in peripheral blood cells among the MPN patients(P＜0.05).JAK2V617F gene mutation was detected in 6 cases of polycythemia vera (PV) and 4 cases of essential thrombocythemia (ET) patients were detected the JAK2V617F mutation,with the positive rates of 83.33％ and 75％,respectively.BCR/ABL mutation was detected in all of 9 CML-chronic phase patients.Conclusions Incidence of MPN was the trend of younger.Enlarged spleen was a common sign.It would be an effective means to make accurate diagnosis and avoid misdiagnosis of MPN for combining the continue increasing blood cells and gene mutation of JAK2V617F and BCR/ABL. Key words: neoplasm; proliferative; marrow; BCR/ABL; JAK2V617F