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2015•Unpublished venueRequires access

Advances in pathogenesis and treatment of myeloproliferative neoplasms

Dayong Huang

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Abstract

As originated from hematopoietic stem cell clonal diseases, bcr-abl-negative chronic myeloproliferative neoplasms (MPN) include polycythemia vera(PV), essential thrombocythemia(ET) and primary myelofibrosis (PMF). With the discovery of JAK2 mutations, many new mutations have been identified. With the in-depth study of gene mutation, the pathogenesis of MPN has been gradually uncovered. Novel drugs have been developed accordingly. Key words: Myeloproliferative neoplasms; JAK2 gene; Gene mutation; Therapy

About this research paper

What this paper is about

As originated from hematopoietic stem cell clonal diseases, bcr-abl-negative chronic myeloproliferative neoplasms (MPN) include polycythemia vera(PV), essential thrombocythemia(ET) and primary myelofibrosis (PMF). With the discovery of JAK2 mutations, many new mutations have been identified. With the in-depth study of gene mutation, the pathogenesis of MPN has been gradually uncovered. Novel drugs have been developed accordingly. Key words: Myeloproliferative neoplasms; JAK2 gene; Gene mutation; Therapy

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Available abstract

As originated from hematopoietic stem cell clonal diseases, bcr-abl-negative chronic myeloproliferative neoplasms (MPN) include polycythemia vera(PV), essential thrombocythemia(ET) and primary myelofibrosis (PMF). With the discovery of JAK2 mutations, many new mutations have been identified. With the in-depth study of gene mutation, the pathogenesis of MPN has been gradually uncovered. Novel drugs have been developed accordingly. Key words: Myeloproliferative neoplasms; JAK2 gene; Gene mutation; Therapy

Key concepts: Essential thrombocythemia, Polycythemia vera, Myelofibrosis, Pathogenesis, Mutation, Cancer research, Haematopoiesis, Gene mutation

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