2018•国际医药卫生导报Requires access
Efficacy of Xuebijing injection combined with CBP in the treatment of acute respiratory distress syndrome in ICU and its effect on blood gas analysis and plasma APN
Xixi Xu
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Abstract
Objective
To observe the efficacy of Xuebijing injection combined with continuous blood purification (CBP) in the treatment of acute respiratory distress syndrome (ARDS) in intensive care unit (ICU) and its effect on blood gas analysis and plasma adiponectin (APN).
Methods
84 cases of ARDS patients treated in ICU of our hospital from June 2016 to December 2017 were selected and randomly divided into observation group (n=42) and control group (n=42). The control group was given basic treatment and CBP, and the observation group was treated with Xuebijing injection on the basis of the control group. The efficacy was compared between the two groups after 1 week of treatment.
Results
After 7 d of treatment, the levels of pH, PaO2, and PaO2/FiO2 in the two groups were significantly higher than those before treatment (P<0.05), and the improvement degree in the observation group was more significant than that in the control group (P<0.05); serum levels of TXB2, IL-8, and ET-1 in the two groups were significantly lower than those before treatment (P<0.05), and the improvement degree in the observation group was more significant than that in the control group (P<0.05); the level of plasma APN in the two groups were significantly higher than those before treatment (P<0.05), and the improvement degree in the observation group was more significant than that in the control group (P<0.05); the scores of ALIS and APACHEII in the two groups were significantly lower than those before treatment (P<0.05), and the improvement degree in the observation group was more significant than that in the control group (P<0.05).
Conclusion
Xuebijing injection combined with CBP for ARDS can improve blood gas results, reduce inflammatory reaction, increase plasma APN level, and relieve acute symptoms and lung injury degree.
Key words:
Xuebijing injection; Continuous blood purification; Acute respiratory distress syndrome