2016•Zhonghua neifenmi daixie zazhiRequires access
The analysis of the changes of maternal thyroid autoantibodies during early pregnancy
Xiaoguang Shi, Cheng Han, Chenyan Li, Jinyuan Mao, Weiwei Wang, Xiaochen Xie, Weiwei Zhou, Chenyang Li, Lihua Bi, Tao Meng, Shaowei Zhang, Jianling Du, Zhengnan Gao, Xiaomei Zhang, Chenling Fan, Zhongyan Shan
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Abstract
Objective
To investigate the changes and related factors of maternal thyroid autoantibodies during early pregnancy.
Methods
Urinary iodine concentration(UIC), serum thyroid stimulating hormone(TSH), free thyroxine(FT4), thyroid-peroxidase antibody(TPOAb), thyroglobulin antibody(TgAb)concentrations were determined in 7 190 women during early pregnancy in an iodine-sufficient region of China.
Results
The prevalence of TPOAb positivity and TgAb positivity were 8.7% and 12.0% respectively. The prevalence of overt hypothyroidism and subclinical hypothyroidism increased significantly in group of thyroid antibody positivity. The prevalence of TPOAb positivity and TgAb positivity presented a U-shaped curve, ranging from mild iodine deficiency to iodine excess, especially increased significantly in the group with UIC<100 μg/L.
Conclusion
Prevalence of thyroid antibodies positivity became higher during early pregnancy. The positive thyroid autoantibodies during pregnancy were significantly associated with maternal hypothyroidism. Both iodine excess and iodine deficiency are risk factors of positive thyroid antibodies. (Chin J Endocrinol Metab, 2016, 32: 376-379)
Key words:
Thyroid; Pregnancy; Thyroid antibody; Iodine