The change and significance of stem cell factor of the rats with varicocele

Objective To investigate the change and significance of stem cell factor (SCF) of the rats with varicocele.Methods To fed twenty cleaning wistar male SD rats for a week,10 rats were randomly selected and which was inducted varicocele group by partial ligation of the left renal vein.Another 10 rats set up for the sham group.The rats of both groups were killed after 60 days,take the postmortem testis and epididymis.We detected the SCF in serum and testicular tissue and detected the density and survival rate of epididymal sperm.Results Compared with the model group,the sham group on sperm density (4.07 ± 1.40) was significantly higher (P ＜ 0.05 ),epididymal sperm motility were not significantly different ( P ＞ 0.05 ).Sham group testes SCF (654.60:±:30.50 ) ng/L significantly decreased ( P ＜ 0.05 )than the model group.SCF in serum showed no significant difference between the groups (P ＞ 0.05 ).Conclusion SCF in testis might serve as an indicator of spermatogenic cells injury. Key words: Varicocele;  SCF;  Infertility;  Testis