2002•中国行为医学科学Requires access

C-Fos protein expression of the rats on the brain stem after sleep deprivation immediately or 1 hour sleep later

宋国萍, 皇甫恩, 苗丹民, 陈足怀

Abstract

目的探索睡眠剥夺和睡眠剥夺后恢复睡眠1小时后脑干中c-Fos蛋白的表达.方法采用小平台水环境法建立大鼠睡眠剥夺模型,用Fos蛋白免疫组化的方法分别测量睡眠剥夺24小时组、睡眠剥夺24小时后恢复睡眠1小时组、大平台对照组、正常单独饲养组脑中Fos蛋白的表达,每组4只.结果睡眠剥夺使Fos蛋白在脑干中不同区域的表达不同,主要区域有孤束核、臂旁核、脑桥被盖核、脑桥网状结构、蓝斑下核及被盖背外侧核;睡眠剥夺后1小时大鼠大部分时间在睡眠,并且上述区域Fos蛋白表达阳性程度减轻,为中低密度.结论睡眠剥夺后1小时的恢复性睡眠可以使脑中c-Fos蛋白表达减轻.

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Key concepts: Sleep (system call), Sleep deprivation, Endocrinology, Internal medicine, Circadian rhythm, Neuroscience, Medicine, Biology