Research on PTEN and tumor and PTEN gene therapy

FTEN is the first tumor suppressor gene to be found which has the phosphorylase function so far.PTEN functional loss is closely related with the tumor.This genetic disorder will cause the protein expression decreased,then will lose tumor suppressor function.Currently,the PTEN gene's research has involved in its treatment research.The wild PTEN gene in the malignant tumor genome team replaces the mutational PTEN gene in cancer cells mainly by the transgene technology and displays normal PTEN's tumor suppressor function.Now we makes a summary on the current PTEN discovery,structure,function mechanism and the relationship between the tumor and its gene thempy. Key words: PTEN; Tumor; Gene therapy; Progress