1997•中华器官移植杂志Requires access
Effects of homogenous embryonic spinal cord grafts on the repair of structure and function after spinal cord injury in adult rats
赵刚, 廖维宏, 蔡锦方, 张亚彬
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Abstract
To study the effect of homogenous embryonic spinal cord grafts on the repair of structure and function of the injured spinal cord in adult rats,fetal embryonic rat spinal cord tissue was transplanted to the hemisection cavity at lumbar spinal cord in adult rats.The behavioral score,evoked potentials were evaluated and histological examination performed after the operation.It was found that the transplants could survive,grow,differentiate,repair the injured spinal cord tissue,induce the reconstruction of the nerve fibre connections,improve the neurotransmission and promote the function recovery of the host rats at the injured sites.It was suggested that the homogenous embryonic spinal cord tissue transplants could assist anatomical and functional repair in the traumatized spinal cord of adult rats.
Key words:
Intraspinal grafting; Fetal spinal cord tissue; Spinal cord injury and repair