Research advances in platelet-derived growth factor and platelet-derived growth factor receptor in the genesis and development of glioma

Gliomas are primary tumor originated from the glial cells of the central nervous system, with the characteristics of unrestricted proliferation and widespread invasion to the surrounding normal brain tissue. The aberrant expression of the platelet-derived growth factor (PDGF) and its membrane receptor (PDGFR) activates the downstream signaling pathway, which affects the development of human glioma, but the molecular mechanisms remain unclear. PDGF and PDGFR play an important role in embryonic development and cell differentiation. PDGF-induced glioma animal model provides an important research method for the study of PDGF signaling pathway in the development of glioma. This article reviews the role of platelet-derived growth factor and its receptor in the development of glioma. Key words: Platelet-derived growth factor; Platelet-derived growth factor receptor; Glioma; Animal model