2009•Int J BiologicalsRequires access

Advances in research of therapeutic anti-rabies virus antibodies

Jun-yuan Wang

Abstract

Rabies is fatal once clinical signs of severe rabies virus (RV) exposure are present.In order to replace rabies immune globulin from human and equine for postexposure prophylaxis of rabis,RV-neutralizing human monoclonal antibodies (mAb) have been investigated extensively.This review summarizes the therapoutic human mAb CR57 and its complementing mAb CR4098.Expresion systems of mAb are also discussed. Key words: Rabies virus; Antibodies; Monoclonal antibody CR57; Monoclonal antibody CR4098

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Key concepts: Rabies, Monoclonal antibody, Rabies virus, Virology, Lyssavirus, Antibody, Virus, Rhabdoviridae