Research on target controlled infusion sedation for midazolam and sulfentanyl in patients undergoing mechanical ventilation

Objective To observe the effects of continuous injection sedation and target controlled infusion(TCI)sedation with midazolam and sulfentanyl for mechanical ventilation of ICU patients. Methods 62 mechanical ventilation patients were randomly divided into continuous group(n= 31)and TCI group. Continuous group was given sedation with midazolam and sulfentanyl by continuous pumping. Sedation with fentanyl and midazolam pumping was adjusted to keep SAS scores of 3- 4 points and bispectral index(BSI)of 70- 75 in TCI group. The sedation span, sedative consumption and vital signs were measured and recorded. Results Compared with continuous group, the consumption of midazolam[(1.29±0.4)mg·kg- 1·24h- 1]and sulfentanyl[(16.9±4.3)μg·kg- 1·24h- 1]in TCI group was significantly lower(t= 2.875,2.593,all P 0.05).Sedation satisfaction degree(62%) and human adaptation degree(87%) in TCI group were significantly higher than continuous group(χ2= 3.883,2.204,all P<0.05).After sedative administration,HR,MAP and Sp O 2 did not significantly decrease compared with baseline. Conclusion TCI sedation can significantly decrease sedative administration of midazolam and sulfentanyl and increase human adaptation degree for mechanical ventilation ICU patients. TCI sedation could be a safe and effective sedation administration. Key words: Midazolam; Sufentanyl; Hypnotics and Sedatives