Analysis on treatment efficacy of hydrotalcid combined with rabeprazole in treating gastroesophageal reflux disease

Objective To evaluate the clinical efficacy of rabeprazole combined with aluminum magnesium in gastroesophageal reflux disease treatment.Methods From August 2010 to October 2013 in our hospital,40 cases of gastroesophageal reflux disease were randomly divided into two groups,20 cases in observation group,using aluminum magnesium rabeprazole combination therapy,the control group with 20 cases used omeprazole amoxicillin treatment,the degree of improvement in reflux symptoms and esophageal pH changes in two groups were compared after 4 weeks.Results The reflux symptoms disappeared in 19 patients (95％),reflux symptoms did not disappear in 1 case (5％) in the control group reflux symptoms disappeared in 14 patients (70％),reflux symptoms did not disappear in 6 patients (30％),two reflux symptom improvement was statistically significantly different (P ＜ 0.05).In observation group 2 patients (10％) esophageal pH ＜ 4,18 patients (90％) esophageal pH ＞ 4,the control group 5 cases (25％) esophageal pH ＜ 4,15 patients (75％) pH ＞ 4,two esophagus pH changes showed statistical significant differences (P ＜ 0.05).Conclusion The combined aluminum magnesium rabeprazole therapy has good clinical efficacy in the treatment of gastroesophageal reflux disease,deserves to be promoted in clinical practice. Key words: Rabeprazole;  Hydrotalcid;  Gastroesophageal reflux disease