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The clinical value of plasma BNP level in evaluation cardiac function of children with left-to-right shunt congenital heart disease

Fang Ren, Jianfeng Liu

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Abstract

Objective To study the clinical value of plasma BNP level in evaluation cardiac function of children with left-to-right shunt congenital heart disease.Methods 32 children with left-to-right shunt congenital heart disease were selected as the observation group.Then according to the heart load capacity,the observation group children were further divided into right ventricular group(14 cases) and left ventricular group(18 cases).20 cases of normal children were selected as the control group.Then plasma BNP level was determined by ELISA and the left ventricular ejection fraction (LVEF),left ventricular end diastolic diameter(LVEDD),right ventricular end diastolic diameter(RVEDD),pulmonary blood flow/systemic blood flow ratio (Qp/Qs) and left heart Tei indices were determined by echocardiography.Results In the right ventricular group,the BNP level was (360.21 ± 56.78) ng/L,LVEDD was (35.71 ± 6.98) mm,RVEDD was (25.04 ± 5.52) mm,Qp/Qs was (1.74 ± 0.24) and left heart Tei index was (0.34 ±0.12).And in the left ventricular group,the BNP level was (384.57 ±55.18) ng/L,LVEDD was (45.27 ±7.26)mm,RVEDD was (12.34 ±2.18)mm,Qp/Qs was (1.78 ±0.19) and left heart Tei index was (0.36 ±0.11),which were significantly higher than those in the control group (F =307.00,18.92,84.24,91.47,3.44,all P ＜ 0.05).LVEF of the observation group had no obvious difference compared with the control group (F =1.51,P ＞0.05).The plasma BNP level of the right ventricular group was positively correlated with RVEDD,Qp/Qs and left heart Tei index (r =0.634,0.721,0.647,all P ＜ 0.05).The plasma BNP level of the left ventricular group was positively correlated with LVEDD,Qp/Qs and left heart Tei index(r =0.547,0.794,0.745,all P ＜ 0.05).There was no correlation between the plasma BNP level and LVEF of the observation group.Conclusion The plasma BNP level can help evaluation the early cardiac function of children with left-to-right shunt congenital heart disease,and combined with echocardiography can accurately reflect the early cardiac function of the left-to-right shunt congenital heart disease,which can provide basis for the clinical diagnosis and treatment. Key words: Heart defects, congenital ;  Natriuretic peptide, brain;  Heart function tests;  Child

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Objective To study the clinical value of plasma BNP level in evaluation cardiac function of children with left-to-right shunt congenital heart disease.Methods 32 children with left-to-right shunt congenital heart disease were selected as the observation group.Then according to the heart load capacity,the observation group children were further divided into right ventricular group(14 cases) and left ventricular group(18 cases).20 cases of normal children were selected as the control group.Then plasma BNP level was determined by ELISA and the left ventricular ejection fraction (LVEF),left ventricular end diastolic diameter(LVEDD),right ventricular end diastolic diameter(RVEDD),pulmonary blood flow/systemic blood flow ratio (Qp/Qs) and left heart Tei indices were determined by echocardiography.Results In the right ventricular group,the BNP level was (360.21 ± 56.78) ng/L,LVEDD was (35.71 ± 6.98) mm,RVEDD was (25.04 ± 5.52) mm,Qp/Qs was (1.74 ± 0.24) and left heart Tei index was (0.34 ±0.12).And in the left ventricular group,the BNP level was (384.57 ±55.18) ng/L,LVEDD was (45.27 ±7.26)mm,RVEDD was (12.34 ±2.18)mm,Qp/Qs was (1.78 ±0.19) and left heart Tei index was (0.36 ±0.11),which were significantly higher than those in the control group (F =307.00,18.92,84.24,91.47,3.44,all P ＜ 0.05).LVEF of the observation group had no obvious difference compared with the control group (F =1.51,P ＞0.05).The plasma BNP level of the right ventricular group was positively correlated with RVEDD,Qp/Qs and left heart Tei index (r =0.634,0.721,0.647,all P ＜ 0.05).The plasma BNP level of the left ventricular group was positively correlated with LVEDD,Qp/Qs and left heart Tei index(r =0.547,0.794,0.745,all P ＜ 0.05).There was no correlation between the plasma BNP level and LVEF of the observation group.Conclusion The plasma BNP level can help evaluation the early cardiac function of children with left-to-right shunt congenital heart disease,and combined with echocardiography can accurately reflect the early cardiac function of the left-to-right shunt congenital heart disease,which can provide basis for the clinical diagnosis and treatment. Key words: Heart defects, congenital ;  Natriuretic peptide, brain;  Heart function tests;  Child

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Available abstract

Objective To study the clinical value of plasma BNP level in evaluation cardiac function of children with left-to-right shunt congenital heart disease.Methods 32 children with left-to-right shunt congenital heart disease were selected as the observation group.Then according to the heart load capacity,the observation group children were further divided into right ventricular group(14 cases) and left ventricular group(18 cases).20 cases of normal children were selected as the control group.Then plasma BNP level was determined by ELISA and the left ventricular ejection fraction (LVEF),left ventricular end diastolic diameter(LVEDD),right ventricular end diastolic diameter(RVEDD),pulmonary blood flow/systemic blood flow ratio (Qp/Qs) and left heart Tei indices were determined by echocardiography.Results In the right ventricular group,the BNP level was (360.21 ± 56.78) ng/L,LVEDD was (35.71 ± 6.98) mm,RVEDD was (25.04 ± 5.52) mm,Qp/Qs was (1.74 ± 0.24) and left heart Tei index was (0.34 ±0.12).And in the left ventricular group,the BNP level was (384.57 ±55.18) ng/L,LVEDD was (45.27 ±7.26)mm,RVEDD was (12.34 ±2.18)mm,Qp/Qs was (1.78 ±0.19) and left heart Tei index was (0.36 ±0.11),which were significantly higher than those in the control group (F =307.00,18.92,84.24,91.47,3.44,all P ＜ 0.05).LVEF of the observation group had no obvious difference compared with the control group (F =1.51,P ＞0.05).The plasma BNP level of the right ventricular group was positively correlated with RVEDD,Qp/Qs and left heart Tei index (r =0.634,0.721,0.647,all P ＜ 0.05).The plasma BNP level of the left ventricular group was positively correlated with LVEDD,Qp/Qs and left heart Tei index(r =0.547,0.794,0.745,all P ＜ 0.05).There was no correlation between the plasma BNP level and LVEF of the observation group.Conclusion The plasma BNP level can help evaluation the early cardiac function of children with left-to-right shunt congenital heart disease,and combined with echocardiography can accurately reflect the early cardiac function of the left-to-right shunt congenital heart disease,which can provide basis for the clinical diagnosis and treatment. Key words: Heart defects, congenital ;  Natriuretic peptide, brain;  Heart function tests;  Child

Key concepts: Medicine, Cardiology, Ejection fraction, Internal medicine, Ventricular function, Cardiac function curve, Shunt (medical), Heart disease

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