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Expression of c-fos Protooncogene Protein (FOS) in the Rat Brain After Cerebral Ischemic Pretreatment

马建荣, G.H. Shahidi Bo

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Abstract

目的 探讨脑缺血预处理后脑组织原癌基因c-fos基因表达蛋白FOS变化及其与脑缺血耐受产生之间的关系.方法 通过建立大鼠全脑缺血模型,采用兔抗c-fos原癌基因抗体SABC免疫组化技术对脑缺血再灌注后的海马神经元进行检测FOS表达.结果 实验鼠四血管阻断(预处理)3min后,12h组、24h组及72h组FOS表达均显著高于对照组(假手术组),P值均＜0.01,72h组最为显著.结论 大鼠短暂非损伤性3min缺血再灌注72h后脑内海马神经元中FOS表达显著增高.FOS表达增高是脑缺血耐受保护机制的一部分.

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目的 探讨脑缺血预处理后脑组织原癌基因c-fos基因表达蛋白FOS变化及其与脑缺血耐受产生之间的关系.方法 通过建立大鼠全脑缺血模型,采用兔抗c-fos原癌基因抗体SABC免疫组化技术对脑缺血再灌注后的海马神经元进行检测FOS表达.结果 实验鼠四血管阻断(预处理)3min后,12h组、24h组及72h组FOS表达均显著高于对照组(假手术组),P值均＜0.01,72h组最为显著.结论 大鼠短暂非损伤性3min缺血再灌注72h后脑内海马神经元中FOS表达显著增高.FOS表达增高是脑缺血耐受保护机制的一部分.

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Available abstract

目的 探讨脑缺血预处理后脑组织原癌基因c-fos基因表达蛋白FOS变化及其与脑缺血耐受产生之间的关系.方法 通过建立大鼠全脑缺血模型,采用兔抗c-fos原癌基因抗体SABC免疫组化技术对脑缺血再灌注后的海马神经元进行检测FOS表达.结果 实验鼠四血管阻断(预处理)3min后,12h组、24h组及72h组FOS表达均显著高于对照组(假手术组),P值均＜0.01,72h组最为显著.结论 大鼠短暂非损伤性3min缺血再灌注72h后脑内海马神经元中FOS表达显著增高.FOS表达增高是脑缺血耐受保护机制的一部分.

Key concepts: Chemistry, Endocrinology, Internal medicine, Gene expression, Biology, Gene, Molecular biology, Cell biology

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Expression of c-fos Protooncogene Protein (FOS) in the Rat Brain After Cerebral Ischemic Pretreatment — Research Paper | ScholarLens