Contrasted research of iodized oil and nonionic iodinated contrast media in hysterosalpingography

Objective To discuss the image quality and adverse effects among different kinds of iodinated contrast media in hysterosalpingography (HSG). Methods From May 2003 to November 2011, a total of 99 female infertile patients were included in the study.They were divided into three groups according to different iodinated contrast media in HSG, group A(n=33, 40% iodized oil), group B(n=33, iopamidol injection) and group C(n=33, iohexol injection). The HSG image quality and adverse effects were recorded. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of West China Second University Hospital.Informed consent was obtained from each participants. Results ①HSG results of 22 cases(22.2%)showed intrauterine adhesion, 53 cases(53.5%)showed infertility.②The scores of HSG image quality was (2.5±0.5) score in group A, (2.4±0.5) score in group B, (2.2±0.4) score in group C, and the differences were significant among three groups(H=6.680, P=0.034). ③There were significant differences among three goups in adverse effects(χ2=7.155, P=0.028). Conclusions Three kinds of iodinated contrast media can all be applied in HSG. For nonionic iodinated contrast media, the higher of iodinated concentration, the better of image contrast, which makes image quality much better. For 40%iodized oil, the image quality was the best but the adverse effects were obvious. Key words: Hysterosalpingography; Contrast media; Image quality; Adverse effects