Effects of 1,25-dihydroxyvitamin D3 in acute rejection of rat renal transplantation

Objective To study the effects of 1,25-dihydroxyvitamin D3(1,25-(OH)2D3)on acute rejection of rat renal transplantation and the mechanism of its immunoloregulation.Methods Kidney transplantation from Wismr rats to SD rats was used as a model of study.Twenty-four SD rats were divided into 4 groups randomly.The levels of BUN,Cr,Ca2+,P3+,IL-2,and IFN-γ in serum were determined.HE staining inspected all specimens of kidney grafts.Results The levels of BUN,Cr,IL-2,and IFN-γ in the group Ⅰ were lower than those in groups Ⅱ,Ⅲ,Ⅳ(P＜0.05),and there was no significant difference in BUN,Cr,IL-2,and IFN-γ between groups Ⅱ andⅢ(P＞0.05),but they were lower in groups Ⅱ and Ⅲ than in group Ⅳ(P＜0.05).The levels of Ca2+ and P3+ in serum had no signigicant difference among groups.The obvious histological change of rejection in grafts were observeed in group Ⅰ.and that Was alleviated in the other groups,especially in group Ⅳ.Conclusion 1,25-(OH)2D3 reduced the acute reiection by decreasing the production of IL-2 and IFN-γ,and ameliorated the function of kidney grafts. Key words: Kidney transplantation;  Aacute rejection;  Immunoloregulation