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The effect of subthreshold stimulation on hippocampal long - termpotentiation in rats

Li Gu

Abstract

目的研究反复的阈下脑放电损伤认知功能的机制.方法在大鼠前额叶皮层给予电刺激,建立惊厥阈下脑放电的动物模型,研究阈下脑放电对大鼠海马突触长时程增强(LTP)的影响.结果前额叶皮层电刺激可引起皮层及海马的惊厥阈下放电.持续3 min的放电可短时间抑制在海马齿状回建立的LTP,这种抑制现象在停止刺激5 min后消失.结论 LTP抑制是阈下放电损伤短时记忆功能的机制之一.此机制可能和N-甲基天冬酸(NMDA)受体通道异常持续开放导致细胞内钙超载有关.

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Key concepts: Subthreshold conduction, Stimulation, Hippocampal formation, Neuroscience, Psychology, Engineering, Voltage, Electrical engineering