2001•中国医师杂志Requires access
Comparison of Efficacy for Diabetic Rats Treated with Two Types of Microencapsulated adult Pig Pancreatic Islets
缪珩, 徐家蓉, 游娜, 于浩泳, 汪晓农
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Abstract
Objective To observe and compare the functions of two typesmicroencapsulated adult pig pancreatic islets in vivo.Methods The diabetic rats induced by streptozocin were divided into four groups:control group,non-encapsulated islet transplantation group,encapsulated islet with sodium alginate membrane transplantation group and encapsulated islet with agarose membrane transplantation group.All rats received intraperitoneal of islet transplantation.Results There were no significant difference in mean level of the blood glucose before transplantation among four groups.On the 7th day after transplantation,the mean level of the blood glucose in four groups were (22.67±1.15)mmol/L，(18.58±2.66)mmol/L(12.27±1.36)mmol/L and (12.38±2.68) mmol/L,respectively.There were significant difference between two encapsulated islet groups as compared with the other two groups(P＜0.01).The survival period of two encapsulated islet transplantation groups were more longer than that of the other two group(P＜0.05 and P＜0.01) respectively.The survival period of encapsulated islet with sodium alginate membrane transplantation group was longer than that of encapsulated islet with agarose membrane transplantation group(P＜0.05).Conclusion Microencapsulated adult pig islets with sodium alginatea and agarose can survive in diabetic rats with their biological activity,but the survival period of encapsulated islet with sodium alginate membrane transplantation group was longer than that of encapsulated islet with agarose membrane transplantation group.