Application progress of immunosuppresive agent in refractory nephritic syndrome in children

Refractory nephrotic syndrome(RNS) is one of the main causes of end-stage renal disease to children and also a difficult issue in clinic treatment.In recent years,the emergence of new immunosuppresive agents greatly improved the prognosis of children with RNS.In this paper,the application progress of immunosuppresive agents such as cyclophosphamide,ciclosporin,tacrolimus,mycophenolate mofetil,leflunomide and rituximab which were commonly used in recent years to different types of children with RNS are summarized. Key words: Immunosuppressive agents;  Children;  Refractory nephritic syndrome