Vitrectomy combined with internal limiting membrane annular peeling and transplantation for the treatment of idiopathic macular hole

Objective To investigate the efficacy of internal limiting membrane (ILM) annular peeling and transplantation in the treatment of giant idiopathic macular hole. Methods Data of 52 eyes of 52 cases with giant idiopathic macular hole(d>500 μm) from Jul.2015 to Dec.2016 were collected and analyzed retrospectively. They were divided randomly into 2 groups: group A, 25 cases, underwent pars plana vitrectomy combined with ILM peeling, and group B, 27 cases, received vitrectomy combined internal limiting membrane peeling and transplantation. After surgery the follow-up time was more than 3 months. Results The visual acuity at 3 months after surgery was 0.86±0.27 in group A and 0.62±0.16 in group B. The difference was statistically significant(t=4.000, P=0.030). Macular hole closure rate was 84% in group A and 100% in group B. The difference was statistically significant(χ2=4.680, P=0.047). Defect of ellipsoid zone was (842.08±146.64)μm in group A and (513.89±85.59)μm in group B. The difference was statistically significant(t=6.920, P=0.010). Conclusion Vitrectomy combined with annular ILM peeling and transplantation for the treatment of giant idiopathic macular hole can increase the rate of macular hole closure and improve the visual function. Key words: Retinal perforations; Vitrectomy; Peeling, limiting membrane, internal, annular; Transplantation, limiting membrane, internal