Value of minimal residual disease detection during induction chemotherapy on prognosis of acute myeloid leukemia

Objective To analyze the relationship between minimal residual disease（MRD） de- tection in AML patients on seventh day of induction chemotherapy and prognosis. Methods The MRD was detected by multi-parameter flow cytometry in 45 cases of primary, newly diagnosed adult AML on seventh day of remission induction chemotherapy. Results Complete remission （CR） rate after the first course in MRD 〈 10-2 group was significantly higher than that in MRD 〉 10-2 group （ 85.7% and 58.3%, respectively, P 〈 0. 05, the difference had statistically significance） ; For patients in MRD 〉 10- 2 group, prolonged the chemotherapy course for a few more days could improve the CR rate （remission rates were 66.7% and 55.6%, but the difference was not statistically significant（ ,P 〉 0. 05 ）. Conclu- sions Detection of MRD on seventh day of remission induction chemotherapy in AML is helpful in pre- dicting the prognosis, as well as providing the basis for prolonging chemotherapy. Key words: Acute myeloid leukemia; Minimal residual disease;  Complete remissionrate