2016•Zhonghua xingwei yixue yu naokexue zazhiRequires access

Proliferation, survival and differentiation of nerve stem cell in rat hippocampal after chronic stress

Wei-juan Qian, Yuxiu Sui

Abstract

Objective To investigate the effect of chronic stress on hippocampal neurogenesis. Methods Chronic unpredictable mild stress(CUMS) was used as animal model to provoke a decrease of neurogenesis in hippocampus. Simultaneously, hippocampal neurogenesis was monitored by assessing cell proliferation, survival, and differentiation. All rats were divided into control group, 14d CUMS group, 28d CUMS group. Results The cell proliferation in 14d CUMS group(2254.17±164.41) or 28d CUMS(1900.33±104.10) group were decreased contrast to the control (2919.50±188.80) (P 0.05). Conclusion These results suggest that chronic stress decreases cell proliferation and survival, but does not affect the phenotype of newborn cells in the hippocampus. Key words: Chronic unpredictable mild stress; Neural stem cell; Hippocampus

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Key concepts: Neurogenesis, Hippocampal formation, Hippocampus, Chronic stress, Neural stem cell, Endocrinology, Cell growth, Internal medicine