The correlation and pathogenesis of estrogen, vitamin D and bone formation related protein in osteoporosis and cardiovascular, cerebrovascular artery calcification.

Objective To explore the correlation and pathogenesis of estrogen, vitamin D and bone formation related protein in osteoporosis, cardiovascular and cerebrovascular artery calcification. Methods Literatures about the relationship between estrogen, vitamin D deficiency and bone formation related protein and osteoporosis or vascular calcification from January 1995 to September 2015 in PubMed and CNKI with the key words estrogen, vitamin D, bone formation related protein, osteoporosis and vascular calcification plaque were selected. The correlation between osteoporosis and the formation of calcified were analyzed and summarized. Results Both estrogen deficiency and vitamin D deficiency had close relationship with osteoporosis and vascular calcification plaque. Osteoprotegerin, adiponectin, bone morphogenetic protein and osteopontin were important cytokines for pathogenesis of osteoporosis associated with vascular calcification plaque. Conclusions Research on the pathogenesis of estrogen, vitamin D and bone formation related protein associated with osteoporosis, cardiovascular and cerebrovascular artery calcification is important for prevention and control of elderly chronic diseases like cardiovascular system diseases and osteoporosis. Key words: Osteoporosis; Vascular calcification; Cytokines; Estrogen; Vitamin D