Advances in the effect of adenosine A2 receptor activation in the prevention and treatment of ischemic diseases

Adenosine, also known as adenine nucleoside, is an important bioactive substances.A large number of studies found that adenosine is involved in the prevention and treatment of many diseases by activating adenosine receptors.Up to now, Adenosine receptors have cloned four subtypes, such as A1, A2a, A2b and A3 and they can be combined with AD and start the downstream signal transduction mechanism, then have different effects on the body.This article will summarize the distribution and activation of adenosine A2 receptor and its role and mechanism in the prevention and treatment of disease. Key words: Adenosine; Adenosine A2 receptor; Adenosine A2 receptor agonist; Ischemic disease