Impact of weight-loss intervention on metabolic indicators in over-weight or obesity adults

Objective To investigate the effects of weight-loss intervention on metabolic indicators in over-weight or obesity adults. Methods A total of 116 over-weight or obese adults entered into this study from March 2008 to December 2009.The participants were divided into three groups by age.Each group received 6 months' weight-loss intervention.Body mass index (BMI), body fat rate, blood pressure, fasting blood glucose (FBG), oral glucose tolerance test (OGTT) 2 h blood glucose, serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured before and after the intervention.The data were analyzed using t test. Results After the intervention, BMI, FBG, TG, and LDL-C were significantly decreased while HDL was significantly increased in each group(P<0.05). Body fat rate, systolic blood pressure, diastolic blood pressure and OGTT 2 h blood glucose were significantly reduced in the young and middle-aged groups(P<0.05), however, there was not significant difference in the older-age group. Conclusions Weight-loss intervention may be effective in improving physical and metabolic indicators in adults with over-weight and obesity and reducing the risk of obesity-related diseases. Key words: Over-weight; Obesity; Adults; Diet, weight-loss