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2014•Chin J PsychiatryRequires access

The abnormalities of regional homogeneity in the resting-state of first-episode medication-nave schizophrenia

Zongling He, Mingli Li, Wei Deng, Qiang Wang, Yinfei Li, Zhuangfei Chen, Yuanyuan Han, Lijun Jiang

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Abstract

Objective To explore the regional homogeneity (ReHo) of resting state brain activity in schizophrenia by using functional magnetic resonance imaging (fMRI). Methods One hundred and four first-episode treatment-nave schizophrenia (FES) patients, and 104 age/gender/education-matched healthy controls were examined by fMRI scans.ReHo of the resting-state brain activity was compared between the two groups. Relationships between abnormal ReHo of brain activity and clinical symptoms in patients were evaluated by partial correlation analysis. Results Compared with controls, FES patients showed significantly decreased regional homogeneity in right orbitofrontal cortex (ReHo: 0.7±0.1, t=-3.502, P<0.05), right dorsolateral prefrontal cortex (ReHo: 1.0±0.1, t=-4.613, P<0.05), left orbitofrontal cortex (ReHo: 0.8±0.1, t=-4.778, P<0.05), posterior cingulate cortex and precuneus (ReHo: 1.2±0.1, t=-3.838, P<0.05), the right lateral parietal cortex (ReHo: 1.1±0.1, t=-4.275, P<0.05) and postcentral gyrus (ReHo: 0.9±0.1,t=-3.520, P<0.05); the FES patients also showed increased ReHo in left anterior (ReHo: 1.1±0.1, t=4.081, P<0.05) and posterior (ReHo: 1.0±0.1, t=3.660, P<0.05) cerebellar lobe, right posterior cerebellar lobe (ReHo: 0.8±0.1, t=3.359, P<0.05), left (ReHo: 0.7±0.1, t=3.986, P<0.05) and right (ReHo: 1.1±0.1, t=3.362, P<0.05) occipital lobe, left superior and middle temporal gyrus (ReHo: 1.1±0.1, t=3.708, P<0.05), left putamen/lentiform nucleus (ReHo: 1.0±0.1, t=4.457, P<0.05). In patients, decreased ReHo in postcentral gyrus was correlated with negative symptoms (r=-0.262, P<0.01) and disorganization symptoms (r=-0.219, P<0.01), decreased ReHo in right orbitofrontal cortex was correlated with withdrawal symptoms (r=-0.242, P<0.01) in schizophrenia. Conclusions Our results indicate that abnormal ReHo of resting-state brain activity may be widely distributed in schizophrenia. The brain regions described above may be involve in the psychopathology and pathophysiology of schizophrenia. Key words: Schizophrenia; Magnetic resonance imaging; Regional homogeneity

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Objective To explore the regional homogeneity (ReHo) of resting state brain activity in schizophrenia by using functional magnetic resonance imaging (fMRI). Methods One hundred and four first-episode treatment-nave schizophrenia (FES) patients, and 104 age/gender/education-matched healthy controls were examined by fMRI scans.ReHo of the resting-state brain activity was compared between the two groups. Relationships between abnormal ReHo of brain activity and clinical symptoms in patients were evaluated by partial correlation analysis. Results Compared with controls, FES patients showed significantly decreased regional homogeneity in right orbitofrontal cortex (ReHo: 0.7±0.1, t=-3.502, P<0.05), right dorsolateral prefrontal cortex (ReHo: 1.0±0.1, t=-4.613, P<0.05), left orbitofrontal cortex (ReHo: 0.8±0.1, t=-4.778, P<0.05), posterior cingulate cortex and precuneus (ReHo: 1.2±0.1, t=-3.838, P<0.05), the right lateral parietal cortex (ReHo: 1.1±0.1, t=-4.275, P<0.05) and postcentral gyrus (ReHo: 0.9±0.1,t=-3.520, P<0.05); the FES patients also showed increased ReHo in left anterior (ReHo: 1.1±0.1, t=4.081, P<0.05) and posterior (ReHo: 1.0±0.1, t=3.660, P<0.05) cerebellar lobe, right posterior cerebellar lobe (ReHo: 0.8±0.1, t=3.359, P<0.05), left (ReHo: 0.7±0.1, t=3.986, P<0.05) and right (ReHo: 1.1±0.1, t=3.362, P<0.05) occipital lobe, left superior and middle temporal gyrus (ReHo: 1.1±0.1, t=3.708, P<0.05), left putamen/lentiform nucleus (ReHo: 1.0±0.1, t=4.457, P<0.05). In patients, decreased ReHo in postcentral gyrus was correlated with negative symptoms (r=-0.262, P<0.01) and disorganization symptoms (r=-0.219, P<0.01), decreased ReHo in right orbitofrontal cortex was correlated with withdrawal symptoms (r=-0.242, P<0.01) in schizophrenia. Conclusions Our results indicate that abnormal ReHo of resting-state brain activity may be widely distributed in schizophrenia. The brain regions described above may be involve in the psychopathology and pathophysiology of schizophrenia. Key words: Schizophrenia; Magnetic resonance imaging; Regional homogeneity

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Available abstract

Objective To explore the regional homogeneity (ReHo) of resting state brain activity in schizophrenia by using functional magnetic resonance imaging (fMRI). Methods One hundred and four first-episode treatment-nave schizophrenia (FES) patients, and 104 age/gender/education-matched healthy controls were examined by fMRI scans.ReHo of the resting-state brain activity was compared between the two groups. Relationships between abnormal ReHo of brain activity and clinical symptoms in patients were evaluated by partial correlation analysis. Results Compared with controls, FES patients showed significantly decreased regional homogeneity in right orbitofrontal cortex (ReHo: 0.7±0.1, t=-3.502, P<0.05), right dorsolateral prefrontal cortex (ReHo: 1.0±0.1, t=-4.613, P<0.05), left orbitofrontal cortex (ReHo: 0.8±0.1, t=-4.778, P<0.05), posterior cingulate cortex and precuneus (ReHo: 1.2±0.1, t=-3.838, P<0.05), the right lateral parietal cortex (ReHo: 1.1±0.1, t=-4.275, P<0.05) and postcentral gyrus (ReHo: 0.9±0.1,t=-3.520, P<0.05); the FES patients also showed increased ReHo in left anterior (ReHo: 1.1±0.1, t=4.081, P<0.05) and posterior (ReHo: 1.0±0.1, t=3.660, P<0.05) cerebellar lobe, right posterior cerebellar lobe (ReHo: 0.8±0.1, t=3.359, P<0.05), left (ReHo: 0.7±0.1, t=3.986, P<0.05) and right (ReHo: 1.1±0.1, t=3.362, P<0.05) occipital lobe, left superior and middle temporal gyrus (ReHo: 1.1±0.1, t=3.708, P<0.05), left putamen/lentiform nucleus (ReHo: 1.0±0.1, t=4.457, P<0.05). In patients, decreased ReHo in postcentral gyrus was correlated with negative symptoms (r=-0.262, P<0.01) and disorganization symptoms (r=-0.219, P<0.01), decreased ReHo in right orbitofrontal cortex was correlated with withdrawal symptoms (r=-0.242, P<0.01) in schizophrenia. Conclusions Our results indicate that abnormal ReHo of resting-state brain activity may be widely distributed in schizophrenia. The brain regions described above may be involve in the psychopathology and pathophysiology of schizophrenia. Key words: Schizophrenia; Magnetic resonance imaging; Regional homogeneity

Key concepts: Orbitofrontal cortex, Medicine, Resting state fMRI, Functional magnetic resonance imaging, Precuneus, Internal medicine, Audiology, Prefrontal cortex

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