2013•Central Plains Medical JournalRequires access

Expression and significance of Axl in chronic myeloid leukemia treated with imatinib

Ming-yin Qiao, Zhongxing Jiang

Abstract

Objective To investigate the relationship between Axl and imatinib resistance.Methods Fifty-nine cases of chronic myeloid leukemia in the first affiliated hospital of Zhengzhou university between March 2009 and May 2012 were selected.The level of Axl mRNA was detected,and the expression levels of patients with different prognosis were compared.Results With the different efficacy of imatinib,Axl mRNA expression level of chronic myeloid leukemia patients were different.Axl mRNA expression levels had significant difference among patients with different treatment effect (P ＜ 0.05).Conclusions Axl is related to imatinib resistance in chronic myeloid leukemia patients.And the overexpression of Axl predicted the high incidence rate of matinib resistance. Key words: Imatinib-resistant; Chronic myeloid leukemia; Axl

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Key concepts: Myeloid leukemia, Imatinib, Medicine, Leukemia, Internal medicine, Incidence (geometry), Myeloid, Chronic leukemia