Classification and clinicopathological analysis of orbital lymphoma

Objeetive To investigate the orbital lymphoma subtypes according to the new classification of the World Health Organization(WHO)and analyze the clinicopathologic features of the different type of orbital lymphoma.Methods A total of 78 cases of orbital lymphoma treated and diagnosed at EENT hospital from January 2002 to June 2006 have been classified using the WHO classification of lymphoma and analyze their clinicopathologic features,treatment and prognoses.Results All the 78 cases were confirmed to be nonHodgkin lymphoma and 77 cases(98.7%)were of B-cell lineage.Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue(MALT lymphoma)is the most commonest(71 case,91.0%),followed by extramedullary plasmacytoma(3 cases,3.8%),follicular lymphoma(1 case,1.3%),diffuse large B-cell lymphoma(1 case,1.3%),precursor B-lymphoblastic lymphoma(1 case,1.3%).1 case(1.3%)of T-cell lineage was peripheral T-cell lymphoma.MALT lymphoma of orbit showed gradual regression treated with local radiotherapy and have a favorable prognosis.Solitarullary plasmacytoma responded to local radiation alone and had no recurrence.Follicular lymphoma and diffuse large B-cell lymphoma responded to local radiation and systemic chemotherapy without disease aggression.The patient of precursor B-lymphoblastic lymphoma and peripheral T-cell lymphoma died of progression of the disease in a short time.Conclusions Various types of lymphoma have different degree of malignancy,clinical manifestation,treatment and prognosis,so the classification of orbital lymphoma is very important. Key words: Orbital neoplasms ;  Lymphoma ;  Classification ;  Pathology,Clinical ;  Therapy ;