Inhibition of corneal neovascularization by Avastin in rabbits

Objective To evaluate the effect of Aavastin to inhibit experimental corneal neovascularization. Methods Twenty rabbits were sutured on the superior cornea. Animals were randomly divided into 2 groups. After 7 days, 10 eyes in the treatment group were given Aavastin drops(4 rog/mi) twice daily, whereas 10 eyes in the control group received placebo (normal saline drops twice daily). The occurrence and developement of CNV was observed on the 3, 7, 14, 21,28 days after suturing by slit-lamp microscope, and the area of CNV was calculated. Fluorescein staining was detected for the integrity of corneal epithelium. Results The occurrence of CNV in group 1 was (3.43±0.53)d and group 2 (3.14±0.69)d. No significant difference in the occurrence time of CNV was found between group 1 and group 2. The CNV areas of group 1 were significantly smaller than that of group 2 at every time poin(P<0.05). The diameter of CNV was significantly smaller after Avastin treatment. Conclusion Avastin can inhibit and restrain corneal neovascularization at some degree without significant side effects. Key words: Avastin; corneal neovascularization; rabbit