Comparison of effects of acute hypervolemic hemodilution with hydroxyethly starch 130/0.4 and polygeline on function of blood clotting in patients undergoing spinal operation

Objective To study the effects of acute hypervolemic hemodilution(AHH) with hydroxyethly starch 130/0.4 and polygeline on function of blood clotting in patients undergoing spinal operation. Methods Forty-five patients scheduled for spinal operation were randomly divided into HS group, PI group and control group with 15 cases for each. Patients in HS group and PI group were respectively performed acute hypervolemic hemodilution by transfusing hydroxyethly starch 130/0.4 and polygeline (15 ml/kg) with 40 ml/min before skin incision. Patients in control group were transfused routinely. Blood samples were taken from internal jugular vein before anesthesia induction(T0), at 1 hour after anesthesia induction (T1) and termination of operation (T2) for determination of Hb, Hct, PLT, PT, APTT, TT and FIB. Results Hb and Hct at T1 and T2 in HS group and PI group were lower than that at T0 and that in control group(P 0.05). PLC and FIB at T1 and T2 in HS group and PI group decreased significantly than that at T0 (P>0.05), while there was no statistical difference between the three groups(P>0.05). PT, TT and APTT had no statistical difference within or between groups(P>0.05). Conclusions Acute hypervolemic hemodilution with hydroxyethly starch 130/0.4 and polygeline has no significant effect on function of blood clotting in patients undergoing spinal operation. Key words: Acute hypervolemic hemodilution;  Hydroxyethly starch;  Polygeline;  Blood clotting;  Spinal column