2011•中国医师杂志Requires access
A clinical observation of pulmonary function changes following three-dimensional conformal radiation therapy in patients with non-small cell lung cancer
Fengyu Li, Xiufang Liu, Shuqi Wang, Guohong Jia, Hai Zhang, Li Wan, Chengbo Ren
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Abstract
Objective To explore the relationships among pulmonary function,DVH and acute radiation pneumonitis after three-dimensional conformal radiation treatment in patients with non-small-cell lung cancer.Methods Pulmonary function tests were conducted on 68 inoperable patients (male 42,female 26,median age 52,KPS≥80) before and after three months radiotherapy respectively.After 3 months of follow-up,radiation pneumonitis were graded,and V20,V30 and MLD were derived from dose volume histogram (DVH).Results All patients were treated with radiotherapy at the irradiation dose of 60～70Gy.Acute radiation pneumonitis occurred in 24 patients with 11 Grade Ⅰ,7 Grade Ⅱ,3 Grade Ⅲ,3 Grade Ⅳ.There were no significant difference between the pre-irradiation and the three months after irradiation for FVC (P＞0.05).But there were significant different between pre-irradiation and three months after irradiation for FEV1.0 and DLCO (P＜0.05).V20,V30 and MLD were observed in patients treated with high radiation pneumonitis.Conclusions There were close relationships among pulmonary function,DVH and radiation pneumonitis in patients with non-small cell lung cancer.
Key words:
Lung neoplasms/RT/PP; Respiratory function tests; Pneumonia/CO; Radiotherapy,conformal/AE