2012•Guoji zhongliuxue zazhiRequires access

CDX gene and tumor

Baohui Yin, Xiu-hong Jia

Abstract

The caudal-type homeobox gene is a member of homeobox gene—Para-HOX family,including CDX1,CDX2 and CDX4.As a transcriptional factor,CDX plays an important role in embryo development,hematopoietic system formation,intestinal epithelium tissue development and so forth.The abnormal expression of CDX is usually closely related with tumorigenesis.Researching the relationship between CDX and tumors will contribute to tumor diagnosis and treatment. Key words: Genes, homeobox ; Neoplasms

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Key concepts: Homeobox, Homeobox A1, CDX2, HNF1B, Homeobox protein Nkx-2.5, Biology, EMX2, Hox gene