Comparison of therapeutic effects of bisoprolol and metoprolol in treatment patients with chronic heart failure

Objective To compare the clinical effects of bisoprolol and metoprolol in treatment patients with chronic heart failure (CHF).Methods 126 patients with CHF were randomly divided into two groups,63 cases in each group.And two groups were treated with bisoprolol or metoprolol based on the conventional anti-HF treatment.The clinical effects of the two groups were compared.Results The total effective rate of the bisoprolol group was 92.1％ (58/63),which was significantly higher than 79.4％ (50/63)in the metoprolol group(P ＜0.05).The HR,SBP,DBP,and LVEF were significantly improved in the two groups after the treatment(P ＜ 0.01).SBP (98.7 ±13.7) mm Hg,LVEF (48.6 ± 7.7)％ in the bisoprolol group were significantly better than (102.5-± 13.8)mm Hg and (45.4 ± 7.9)％ in the metoprolol group after treatment(P ＜ 0.05).But there was no significant difference in the incidence rate of clinical adverse events between the two groups (P ＞ 0.05).Conclusion Bisoprolol and metoprolol can effectively improve the heart function of patients with CHF,but bisoprolol has more advantages,so we should strictly control the indications in the clinical work,to make a reasonable choice of drugs. Key words: Heart failure, congestive ;  Bisoprolol ;  Metoprolol ;  Treatment outcome