Changes and clinical significane of plasma coagulation factor VII and antithrombin III in patients with acute myocardial infarction

Objective To observe changes of plasma coagulation factor Ⅶ(FVII) and antithrombin III( AT-Ⅲ) in patients with acute myacardial infarction(AMI) . Methods The blood samples of 40 patients with AMI and 20 healthy volunteers were obtained through vein at the moment of admission. The plasma activated factors( FVIIag,FVI- la,FVII: C and AT-Ⅲ) were detected with different methods. Results Compared with control group,the plasina levels of FVIIag, FVIIa and the FVII: C in patients with AMI were significantly higher( P < 0.05, P < 0. 01) and especially in FVIIa(P <0.01) ,the AT-Ⅲ activity decreased significantly. Conclusion FVIIa and AT-III play important role in thrombosis of AMI,and the changes of their activities could predict the formation of acute cardiovascular event. Key words: Myocardial infarction; Factor VII; Antithrombin Ⅲ