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THE CLINICAL SIGNIFICANCE OF EXPRESSION OF p16 IN GASTRIC CARCINOMA

宋希林, 马恒, 边家盛, 徐忠法, 郭洪亮, Lei Wang, 李永清

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Abstract

目的:观察p16蛋白在胃癌中的表达规律及其与预后的关系.方法:应用免疫组织化学S-P法,对62例有随访结果的胃癌组织进行p16蛋白检测.结果:有淋巴结转移组p16蛋白阳性率18.9%显著低于无淋巴结转移组48.0%(P＜0.05);p16蛋白阳性组胃癌患者术后5年生存率31.6%(6/19)显著高于p1 6蛋白阴性组9.3%(4/43)(P＜0.05).结论:p16蛋白表达状况可作为临床判断胃癌生物学行为、转移潜能及患者预后的一项重要指标.

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目的:观察p16蛋白在胃癌中的表达规律及其与预后的关系.方法:应用免疫组织化学S-P法,对62例有随访结果的胃癌组织进行p16蛋白检测.结果:有淋巴结转移组p16蛋白阳性率18.9%显著低于无淋巴结转移组48.0%(P＜0.05);p16蛋白阳性组胃癌患者术后5年生存率31.6%(6/19)显著高于p1 6蛋白阴性组9.3%(4/43)(P＜0.05).结论:p16蛋白表达状况可作为临床判断胃癌生物学行为、转移潜能及患者预后的一项重要指标.

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Available abstract

目的:观察p16蛋白在胃癌中的表达规律及其与预后的关系.方法:应用免疫组织化学S-P法,对62例有随访结果的胃癌组织进行p16蛋白检测.结果:有淋巴结转移组p16蛋白阳性率18.9%显著低于无淋巴结转移组48.0%(P＜0.05);p16蛋白阳性组胃癌患者术后5年生存率31.6%(6/19)显著高于p1 6蛋白阴性组9.3%(4/43)(P＜0.05).结论:p16蛋白表达状况可作为临床判断胃癌生物学行为、转移潜能及患者预后的一项重要指标.

Key concepts: Expression (computer science), Medicine, Clinical significance, Oncology, Internal medicine, Computer science, Programming language

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