2010•Int J ImmunolRequires access

Relationship between Smad and transforming growth factor-β signal transduction pathway

Zheng Liu, Jihong Dai, Zhou Fu

Abstract

Members of transforming growth factor-β(TGF β) superfamily play an important roles in regulating cell growth, differentiation and tissue homeostasis. Smad proteins possess special structure and property and play important roles in transforming growth factor-β(TGF-β) signal transduction pathway. TGF-β activates the downstream Smad proteins,which initiate intracellular signaling pathways via its interaction with TGF-β receptor(TGF-βR) . Research on the varieties,structures and function of Smad proteins,and the complicated regulating mechanism of Smad proteins in TGF-β superfamily signaling transduction are very significative. Key words: Transforming growth factor-β; Smad; Signal transduction

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Key concepts: SMAD, Transforming growth factor, Signal transduction, R-SMAD, Cell biology, Smad2 Protein, Biology, Growth differentiation factor