Giant Fibroadenoma of the Breast in Children

This paper reports 9 female cases of giant fibroadenoma of breast.The patients were 13(2 cases),14(5)and 15(2)years old respectively.The longest course of the condition was 6 years and the shortest 1 month in this series.All appeared as a rapid growing mass occupying more than half of the affected breast within a short time.Six tumors were found in the right breast and 3 in the left.Clinical manifestation was characterized by giant mass in the breast with nodular or qobulous appearance.Skin congastion and phlebectasis on the tumor were seen in 3 cases,1 case complicated with ulceration.The resected specimen measurement was from 8 cm to 14 cm in diameter(average 10.6 cm),and microscopic findings showed that 7 cases belonged to intraductal type,and 2 to periductal.The latter was rich in fidrous cells anb showed mitoses.One of the 2 periductal type patients showed epithelial proliferation of glandular duct and feature of mitosis. Simple mastectomy was performed on 2 patients and tumor excision on 7.All the patients were followed up for an average length of 5 years and 7 months.There was no recurrence.The affected breast subject to tumor excision basically developed as well as the contralateral breast and had a,good appearance. The authors noted that the tumor's development be attributed to disturbance of endocrine regulation,especially the stimulation of estrogen.They emphasized the diagnosis be based upon the combination of clinical features,the diameter of the tumor and pathological findings.Excision of the tumor is choice treatment with good result.