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2015•Int J GenetRequires access

Research progress of association between the polymorphisms of APOBEC3G, PSIP1, SAMHD1 gene and HIV-1/AIDS

Qiuyan Li, Yuandong Qiao, Xuelong Zhang

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Abstract

The host genetic background is one of the major factors causing different phenotype between individuals after HIV-1 infection. Many studies found that APOBEC3G, LEDGF/p75, and SAMHD1 play an important role in HIV-1 replication cycle. APOBEC3G has a broad antiviral activity, LEDGF/p75 can tether HIV-1 to the chromosome through interacting with integrase, and SAMHD1 can inhibit HIV-1 replication by its dNTPase and RNase activities. In this review, we summarize the research progress in the polymorphisms of APOBEC3G, PSIP1 and SAMHD1 genes that encode the aforementioned proteins, their susceptibility to HIV-1 infection and association with AIDS. Key words: HIV-1; AIDS; SNP

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What this paper is about

The host genetic background is one of the major factors causing different phenotype between individuals after HIV-1 infection. Many studies found that APOBEC3G, LEDGF/p75, and SAMHD1 play an important role in HIV-1 replication cycle. APOBEC3G has a broad antiviral activity, LEDGF/p75 can tether HIV-1 to the chromosome through interacting with integrase, and SAMHD1 can inhibit HIV-1 replication by its dNTPase and RNase activities. In this review, we summarize the research progress in the polymorphisms of APOBEC3G, PSIP1 and SAMHD1 genes that encode the aforementioned proteins, their susceptibility to HIV-1 infection and association with AIDS. Key words: HIV-1; AIDS; SNP

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Available abstract

The host genetic background is one of the major factors causing different phenotype between individuals after HIV-1 infection. Many studies found that APOBEC3G, LEDGF/p75, and SAMHD1 play an important role in HIV-1 replication cycle. APOBEC3G has a broad antiviral activity, LEDGF/p75 can tether HIV-1 to the chromosome through interacting with integrase, and SAMHD1 can inhibit HIV-1 replication by its dNTPase and RNase activities. In this review, we summarize the research progress in the polymorphisms of APOBEC3G, PSIP1 and SAMHD1 genes that encode the aforementioned proteins, their susceptibility to HIV-1 infection and association with AIDS. Key words: HIV-1; AIDS; SNP

Key concepts: SAMHD1, APOBEC3G, Biology, Genetics, Virology, Gene, Integrase, Human immunodeficiency virus (HIV)

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Research progress of association between the polymorphisms of APOBEC3G, PSIP1, SAMHD1 gene and HIV-1/AIDS — Research Paper | ScholarLens