Research Progress of Characteristics of Behavioral Manifestations and Interventions of Perinatal Hypoxic-Ischemic Brain Damage Animals

Hypoxic-ischemic encephalopathy (HIE) could induce sensorimotor dysfunction and cognitive deficits, and perinatal asphyxia is the major cause of neonatal HIE. The manifestations of hypoxic-ischemic animal during perinatal period include neurobehavioral deficits and motor function abnormal, especially in the perspective of sensorimotor, cognitive and emotional behavior abilities. This article elaborated the behavioral changes of perinatal hypoxic-ischemic brain damage (HIBD) animals from the perspectives of early neurobehavioral defects, abnormal motor function, abnormal changes in emotional capacity and cognitive defects. Moreover, this paper also summarized effects of drug intervention, pretreatment and environmental enrichment (EE) on the behavioral changes of perinatal HIBD animal. Key words: Hypoxia-ischemia, brain; Perinatal; Neurobehavioral manifestations