2003•医师进修杂志Requires access

THE EXPRESSION OF PLATELET DERIVED GROWTH FACTOR IN LUNG SQUMOUS CELL CARCINOMA AND ADENOCARCINOMA

欧阳瑶, 邓飞, 李春鸣, 刘华庆

Abstract

目的探讨血小板衍生生长因子(PDGF)在肺鳞癌和肺腺癌中的表达及意义.方法应用免疫组织化学技术观察了PDGF-A链和 PDGF-B链在42例肺鳞癌和15例肺腺癌中的表达,并测定了它们在肺非特异性炎症组织中的表达.结果 PDGF-A链和PDGF-B链的表达主要定位于肿瘤细胞胞浆、血管内皮细胞及平滑肌细胞,炎症组织的肺泡上皮细胞及血管平滑肌细胞少量表达.PDGF-A链和PDGF-B链在肺鳞癌及肺腺癌中均有显著表达;PDGF的过度表达与肿瘤细胞的分化程度无关.结论 PDGF-A链和PDGF-B链的过度表达与肺鳞癌和肺腺癌有关;PDGF-A链和PDGF-B链的生物学特征可能有所不同,PDGF-B链与肿瘤微血管增生的关系可能更密切.

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Key concepts: Adenocarcinoma, Expression (computer science), Carcinoma, Lung cancer, Lung, Adenocarcinoma of the lung, Platelet, Cancer research