2009•Int J Cerebrovasc DisRequires access
Pharmacological mechanisms and clinical application of mannitol in intracerebral hemorrhage
Hongxia Nie
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Abstract
One of the important therapeutic measures in the acute stage of cerebral hemorrhage is to treat cerebral edema and lower intracranial pressure. Mannitol, an osmotic dehydrant, is most widely used in clinical practice. Its major effects include the reduction of intracranial pressure and cerebral edema and prevention of cerebral herniation. Besides, rnannitol scavenges oxygen free radicals and protects brain cells. So it has extremely important significance in reducing the mortality of intracerebral hemorrhage.
Key words:
mannitol; intracerebral hemorrhage; pharmacological processes; clinical application