Research progress in factors involved in the first meiotic division in spermatogenesis

Spermatogenesis is a highly complex and unique process of cell proliferation and differentiation in reproductive cells. Spermatogenesis is controlled by many factors; among them some genes and specific protein factors, RNAs, enzymes play essential roles. Meiosis is an important link in the process of spermatogenesis. There are lots of associated factors in meiosis and spermatogenesis whose change or deletion can affect the spermatogenesis and disable the formation of a normal mature sperm. The deletion mutation of genes such as Scp3、M1ap、TEX11、Spata22、Smc6、Ku70、TSF22, and absence of correlation factors and enzymes, can also affect the first meiotic division and spermatogenesis. In this paper, we review these factors that influence the first meiosis division. Key words: Spermatogenesis; First meiotic division; Gene; Enzyme