Progress in the treatment of osteoarthritis based on subchondral bone

Osteoarthritis (OA) is a common and disabling joint disorder, which is mainly characterized by cartilage degeneration and narrow joint space. Nowadays, the research on the therapy of OA is no longer limited to articular cartilage. Subchondral bone plays an important role in the genesis and development of OA, both in structure and biological function. This article briefly reviews the structural and functional association of subchondral bone and cartilage and the pathological change of subchondral bone in OA. The progress in the treatment of osteoarthritis based on subchondral bone was emphatically reviewed, and a global visualized analysis of subchondral bone in recent twenty five years was shared. Key words: Subchondral bone; Osteoarthritis; Therapy; Visualized analysis