Treatment of painful neuroma by intraneural injection of adriblastine combined with neuroma resection or neurolysis

Objective To introduce a novel method to treat painful neuroma and evaluate the preliminary clinical outcomes.Methods From 2002 to 2006,9 patients with painful neuromas were treated.The surgical technique included neuroma resection and embedding of the proximal nerve end into adjacent normal soft tissue in 8 patients and neurolysis in 1 patient.According to the size of the nerve,0.3 to 1.0 ml of 1% adriblastine was injected into the proximal nerve stump.Results The mean follow-up was 34 months (range,24 to 60 months).Seven of the 9 patients experienced complete and permanent pain relief.Some mild degree of pain returned in 1 patient.Postoperative pain level was not changed for the patient who underwent neurolysis and intraneural adriblastinc injection.The overall effective rate was 77.8%.Conclusion Stump pain caused by painful neuroma can be effectively treated by neuroma resection and intraneural adriblastine injection Key words: Peripheral nerve; Neuroma; Pain; Surgical prccedures,operative; Adriblastine