2009Zhongguo xiaoer jijiu yixueRequires access

Significance of serum cytokine in children with allergic purpura

刘文东, 李红, 王彩霞, 于凌翔, 金心

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Abstract

目的 研究肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6和IL-8在过敏性紫癜和紫癜性肾炎发病中的作用.方法 采用双抗体夹心ELISA法检测过敏性紫癜患儿血清TNF-α、IL-6和IL-8的水平.结果 过敏性紫癜急性发病期血清TNF-α、IL-6和IL-8水平较对照组明显增高(P<0.01);在恢复期,TNF-α、IL-6和IL-8则明显下降;紫癜性肾炎时TNF-α、IL-6、IL-8水平较过敏性紫癜时有所增高(P<0.05).结论 TNF-α、IL-6和IL-8在过敏性紫癜和紫癜性肾炎的发病中发挥了一定的作用。

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目的 研究肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6和IL-8在过敏性紫癜和紫癜性肾炎发病中的作用.方法 采用双抗体夹心ELISA法检测过敏性紫癜患儿血清TNF-α、IL-6和IL-8的水平.结果 过敏性紫癜急性发病期血清TNF-α、IL-6和IL-8水平较对照组明显增高(P<0.01);在恢复期,TNF-α、IL-6和IL-8则明显下降;紫癜性肾炎时TNF-α、IL-6、IL-8水平较过敏性紫癜时有所增高(P<0.05).结论 TNF-α、IL-6和IL-8在过敏性紫癜和紫癜性肾炎的发病中发挥了一定的作用。

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Available abstract

目的 研究肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6和IL-8在过敏性紫癜和紫癜性肾炎发病中的作用.方法 采用双抗体夹心ELISA法检测过敏性紫癜患儿血清TNF-α、IL-6和IL-8的水平.结果 过敏性紫癜急性发病期血清TNF-α、IL-6和IL-8水平较对照组明显增高(P<0.01);在恢复期,TNF-α、IL-6和IL-8则明显下降;紫癜性肾炎时TNF-α、IL-6、IL-8水平较过敏性紫癜时有所增高(P<0.05).结论 TNF-α、IL-6和IL-8在过敏性紫癜和紫癜性肾炎的发病中发挥了一定的作用。

Key concepts: Medicine, Purpura (gastropod), Immunology, Cytokine, Dermatology, Ecology, Biology

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