Tumor metastasis suppressor gene MIM

Tumor metastasis suppressor genes is a kind of genes that only suppresses tumor metastasis without affecting tumorigenesis and tumor growth. MIM ( missing in metastasis ) is a putative tumor metastasis suppressor gene discovered recently, which is thought to be down-regulated generally in some metastatic bladder cancer and prostate cancer cells in comparison with normal bladder and prostate tissue. MIM, localized in chro-mosome 8q24.1, suggests a connection with regulation of cytoskeleton with a proline-rich region and a homology 2 (WH2) domain binding the actin. MIM also has support roles for its multiple-domain. Its potential homo-logue MIM-B is also thought to code a putative tumor metastasis suppressor protein. Key words: Genes,tumor suppressor;  Neoplasm metastasis