Etiological analysis of common and severe hand-foot-mouth disease in kunming and surrounding areas of 2010

Objective To analyze the etiological pathogenesis between common hand-foot-mouth disease (HFMD) and severe HFMD in kunming and surrounding areas of 2010,and study significance of clinical manifestations caused by hand-foot-mouth disease in molecular epidemiology.Methods The clinical data of 1304 children with HFMD in children hospital of Kunming from January to December in 2010 were collected,and at the same time,1272 cases of stool specimens (518 cases of common HFMD,severe HFMD 754 cases) did half nested RT-PCR detection and nucleic acid sequencing cause credits type.Results Eleven kinds of pathogens were detected in common HFMD cases,coxsackie virus group A(CA),CA(60.4％) (the main CA16)was highest proportion.The difference were statistically significant(x2 =579.78,P ＜0.01),CA (mainly CA16) for common HFMD were the main pathogen.In severe HFMD cases,8 kinds of pathogens were detected,the proportion of CA (45.6％) and EV71 (29.2％) were higher than other pathogens,CA (mainly CA16) and EV71 were the main pathogen in severe HFMD.But CA infection case of 52.4％ were severe,47.6％ were the common type,the difference had no statistically significant(x2 =1.46,P ＞ 0.05).While the EV71 infection rate 70.3％ was severe type,29.7％ was common type,the difference was statistical significant(x2 =51.53,P ＜ 0.01),EV71 infection in children with HFMD likely to develop into severe HFMD.Conclusions Many kinds of pathogens are detected in Kunming and the surrounding areas of children with HFMD in 2010,but main pathogens are EV71 and CA16,CAl6 is the main pathogens of common HFMD,CA16 and EV71are the main pathogens of severe HFMD.But EV71 infection in children with HFMD likely to develop into severe HFMD. Key words: Hand-foot-mouth disease ;  Severe ;  Common ;  Enterovirus ;  Etiology