2009Int J BiologicalsRequires access

Current status of research and development of meningococcal vaccines

Yuan-xiang Jiang, Wei Zhu

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Abstract

Meningococcal disease remains a major public health problem throughout the world,with associated high levels of morbidity and mortality.In this review,research and development of meningococcal vaccines and group B meningococcal vaccine in particular are discussed in the following aspects,including bacterial genetics,epidemic of meningococcal disease,vaccine supply,new candidate vaccines and new methods to identify meningococcal vaccine candidates. Key words: Neisseria meningitidis; Vaccines,conjugate; Outer membrane vesicle

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What this paper is about

Meningococcal disease remains a major public health problem throughout the world,with associated high levels of morbidity and mortality.In this review,research and development of meningococcal vaccines and group B meningococcal vaccine in particular are discussed in the following aspects,including bacterial genetics,epidemic of meningococcal disease,vaccine supply,new candidate vaccines and new methods to identify meningococcal vaccine candidates. Key words: Neisseria meningitidis; Vaccines,conjugate; Outer membrane vesicle

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Available abstract

Meningococcal disease remains a major public health problem throughout the world,with associated high levels of morbidity and mortality.In this review,research and development of meningococcal vaccines and group B meningococcal vaccine in particular are discussed in the following aspects,including bacterial genetics,epidemic of meningococcal disease,vaccine supply,new candidate vaccines and new methods to identify meningococcal vaccine candidates. Key words: Neisseria meningitidis; Vaccines,conjugate; Outer membrane vesicle

Key concepts: Neisseria meningitidis, Meningococcal vaccine, Meningococcal disease, Medicine, Virology, Immunology, Biology, Bacteria

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