Anemia in patients with diabetic nephropathy who undergoing maintenance hemodialysis in Xinxiang areas

Objective To investigate present situation and related factors of anemia in patients with diabetic nephropathy who received maintenance hemedialysis (MHD).Methods A total of 364 patients who underwent MHD in four hospitals of Henan Province were enrolled and assigned to the diabetes group (n =98,male 44,female 54,mean age (60± 12) years old) and the non-diabetes group (n =266,male 165,female 101,mean age (48 ± 17) years old).Relationship between hemoglobin levels with erythropoietin(EPO),iron,malnutrition,adequacy of dialysis,inflammation and parathyroid hormone (PTH) was analyzedin all the participants.Student' s t test or Chi-square test was used for data analysis.Results Incidence of anemia was higher in the diabetes group than the non-diabetes group (78.6％ vs 67.3％,P＜0.05).The level of serum hemoglobin and the rote of hemoglobin target were significantly decreased in the diabetes group ((90 ± 19) vs(96 ± 23) g/L,21.4％ vs 32.7％; both P ＜ 0.05).The level of serum albumin,prealbumin,dialysis age and PTH were significantly lower,and the level of dialysis frequency wassignificantly higher in the diabetes group than the non-diabetes group ((37 ± 6) vs (39 ± 5) g/L,(483 ±143) vs (586 ± 138) mg/L,(23 ± 22) vs (34 ± 26) months,(77 ± 132) vs (155 ± 240) pmol/L; all P ＜0.01).Serum levels of CRP and calcium in the diabetes group were significantly higher than those in the non-diabetes group ((8± 14) vs (3± 10) mg/L,(2.0±0.4) vs (1.9±0.3) tmol/L; both P＜0.05).There were no significant differences in EPO dose,treatment rate and standard rate of iron between the two groups (all P＞0.05).Conclusion In the case of using the same dose of EPO,the incidence ofanemiais high and the rate of hemoglobin target is low in MHD patients with diabetes,which is associated with inflammation and malnutrition.It is important to treat anemic MHD patients with enough EPO and iron,in the meantime,more attention must be put to the treatment of malnutrition and inflammation. Key words: Diabetes mellitus ;  Anemia ;  Dialysis ;  Erythropoietin ;  Inflammation ;